Scientific Name: Tea Tree Oil
Other Names: Melaleuca Oil, Oleum Melaleucae, TTO

Who is this for?

Uses

Note: Taking tea tree oil by mouth may cause possibly serious side effects such as confusion, loss of muscle control, or coma. Even small amounts of tea tree oil may be harmful if swallowed by young children or household pets. Using tea tree oil orally is not recommended due to these risks.

Tea tree oil is applied topically as an anti-infective agent. It has been shown effective for bacterial infections (such as acne), fungal infections (such as athlete's foot), and viral infections (such as cold sores). It contains chemicals known as terpenes, which may damage or kill infective organisms, while having little or no negative effect on generally harmless bacteria that normally live on the skin. Because tea tree oil is usually non-irritating, it is also applied to relieve mild burns, insect bites, sunburn, and other relatively minor skin conditions.

In dentistry, tea tree oil has been used to kill bacteria in the mouth before dental surgery and to relieve mouth soreness caused by dental procedures. It has also been included in vaginal suppositories to treat vaginal infections. Steam produced when tea tree oil is added to boiling water, nebulizers, or hot baths may be inhaled to relieve nose, throat, and lung irritation. In studies of patients who suffered from oral candidiasis (a fungal infection of the mouth and throat) mouth rinses containing tea tree oil have shown some effectiveness in reducing symptoms. It may also be included in dandruff shampoos.

When should I be careful taking it?

Due to possible toxic effects, taking tea tree oil by mouth is not recommended. One case of coma has been attributed to taking approximately 4 ounces (one-half cup) of tea tree oil by mouth. Another case involved an adult who developed a rash and a significant increase in white blood cells after taking a small amount of tea tree oil by mouth. In another report, a small child who swallowed about 2 teaspoons of tea tree oil showed signs of drowsiness and the inability to coordinate muscle movement. All these individuals recovered completely.

Some reliable evidence associates decreased or lost hearing with the use of 100% tea tree oil in the ear. Therefore, tea tree oil preparations should not be put into the ears.

Precautions

While tea tree oil is usually mild, highly concentrated tea tree oil may irritate the skin. Several cases have been reported of individuals who developed itchy skin rashes from using even modest amounts of tea tree oil or from handling parts of tea trees. Because tea trees contain chemicals similar to those found in the pine tree family, individuals who are sensitive to pine needles or pine resin may also be sensitive to tea tree oil.

What side effects should I watch for?

Side effects reported from the use of tea tree oil on the skin are generally mild and temporary. However, higher concentrations have a greater potential to cause skin irritation. Side effects usually occur at the site of application and they may include:

  • Burning
  • Dryness
  • Irritation
  • Itching
  • Redness
  • Stinging

A few cases have been reported of gynecomastia (enlarged breasts) in young boys who applied products containing tea tree oil, topically. Breast tissue returned to normal after the applications stopped.

What interactions should I watch for?

No interactions have been identified between tea tree oil and prescription drugs, non-prescription drugs, other herbal products or foods. However, not all interactions may be known.

Some interactions between herbal products and medications can be more severe than others. The best way for you to avoid harmful interactions is to tell your doctor and/or pharmacist what medications you are currently taking, including any over-the-counter products, vitamins, and herbals. For specific information on interactions among drugs, herbals, and foods and the severity of those interactions, please use our Drug Interactions Checker to check for possible interactions.

Should I take it?

A number of different trees and bushes that grow in the islands of the south Pacific are known by the name "tea tree" because their bark, leaves, or twigs were used by native people or visiting sailors to make tea substitutes. Australian tea trees--the source of commercial tea tree oil--are really evergreen shrubs that grow in the swampy coastal areas of Australia. They grow relatively quickly, reaching 7 feet or 8 feet in height at maturity. Australian tea trees have soft, thick, light-colored bark. The sweet-smelling, fluffy white flowers that bloom in the summer are followed by seed pods that may take more than a year to mature. For commercial production or tea tree oil, new trees usually are sprouted from cuttings.

The pine-needle-like tea tree leaves are collected at any time during the year and distilled with steam. The resulting light yellow oil smells similar to nutmeg. Due to its pleasant odor and its antiseptic properties, tea tree oil may be included in cosmetic products, shampoos, and soaps. High concentrations of tea tree oil have been studied as insecticides and it has been used to protect garden plants against fungus or mold infections. For humans and animals, it has shown effectiveness against lice and house mites. Because tea tree oil may kill many infective organisms, it has also been used as a disinfectant for various types of industrial equipment and conduits for heating and cooling systems. It has also been added to machine oils in industries, such as ship building, in which a high number of injuries occur among workers. Adding tea tree oil to the machine oils is thought to help prevent infections that may result because of the injuries.

Dosage and Administration

The concentration of tea tree oil in various commercial preparations ranges from about 1% to 100%. Often, the stronger products are used for hard-to-treat infections such as toenail fungus, while 5% to 10% tea tree oil gels have been used successfully to treat acne.

Commonly used dosages and durations include:

  • For acne: 5% tea tree oil once a day indefinitely
  • For athlete's foot: 10% tea tree oil twice a day for one month
  • For fungal infections of fingernails or toenails: 100% tea tree oil twice a day for 6 months
  • For oral candidiasis: one tablespoonful of 5% tea tree oil solution as a mouth wash that is held in the mouth as long as possible and then spit out four times a day for up to 4 weeks


Summary

Tea tree oil may be applied to the skin as an antiseptic. Its anti-infective properties may treat conditions such as acne, athlete's foot, oral candidiasis, and vaginal infections. It may also soothe the irritation of non-infectious conditions such as sunburn.

Risks

Tea tree oil should not be taken by mouth due to possible toxicity. It should not be used in the ears because it may cause hearing loss. In addition, individuals who are sensitive to tea tree and who touch tea trees or who use tea tree oil may develop an allergic rash.

Side Effects

Topical tea tree oil may produce temporary dryness, itching, redness, or stinging at the application site.

If tea tree oil is taken by mouth, possible side effects include:

  • Rash
  • Confusion
  • Drowsiness
  • Loss of muscle coordination
  • Coma

Interactions

No interactions have been identified between tea tree oil and prescription drugs, non-prescription drugs, other herbal products or foods. However, not all interactions may be known.

Last Revised October 19, 2007

References

Aberer W. Contact allergy and medicinal herbs. Journal Der Deutsche Dermatologischen Gesellschaft. Epublished ahead of print. October 5, 2007.

Anon: Tea Tree Oil. In: DerMarderosian A, Beutler JA, eds. Facts and Comparisons: The Review of Natural Products. St. Louis, MO, Facts and Comparisons. November 1997.

Arweiler NB, Donos N, Netuschil L, Reich E, Sculean A. Clinical and antibacterial effect of tea tree oil-a pilot study. Clinical Oral Investigation. 2000;4(2):70-73.

Bagg J, Jackson MS, Petrina Sweeney M, Ramage G, Davies AN. Susceptibility to Melaleuca alternifolia (tea tree) oil of yeasts isolated from the mouths of patients with advanced cancer. Oral Oncology. 2006;42(5):487-492.

Bassett IB, Pannowitz DL, Barnetson RS. A comparative study of tea-tree oil versus benzoyl peroxide in the treatment of acne. Medical Journal of Australia. 1990;153(8):455-458.

Buck DS, Nidorf DM, Addino JG. Comparison of two topical preparations for the treatment of onychomycosis: Melaleuca alternifolia (Tea Tree) oil and clotrimazole. Journal of Family Practice. 1994(6);38:601-605.

Budhiraja SS, Cullum ME, Sioutis SS, Evangelista L, Habanova ST. Biological activity of Melaleuca alternifola [sic] (Tea Tree) oil component, terpinen-4-ol, in human myelocytic cell line HL-60. Journal of Manipulative Physiology and Therapy. 1999;22(7):447-453.

Carson CF, Hammer KA, Riley TV. Melaleuca alternifolia (Tea Tree) oil: a review of antimicrobial and other medicinal properties. Clinical Microbiology Reviews. 2006;19(1):50-62.

Carson CF, Riley TV. Safety, efficacy and provenance of tea tree (Melaleuca alternifolia) oil. Contact Dermatitis. 2001;45(2):65-67.

Del Beccaro MA. Melaleuca oil poisoning in a 17-month old. Veterinary and Human Toxicology. 1995;37(6):557-558.

Enshaieh S, Jooya A, Siadat AH, Iraji F. The efficacy of 5% topical tea tree oil gel in mild to moderate acne vulgaris: a randomized, double-blind placebo-controlled study. Indian Journal of Dermatology, Venereology and Leprology. 2007;73(1):22-25.

Ergin A, Arikan S. Comparison of microdilution and disc diffusion methods in assessing the in vitro activity of fluconazole and Melaleuca alternifolia (tea tree) oil against vaginal Candida isolates. Journal of Chemotherapy. 2002;14(5):465-472.

Ernst E, Huntley A. Tea tree oil: a systematic review of randomized clinical trials. Forsch Komplementarmed Klass Naturheilkd. 2000 Feb;7(1):17-20.

Ernst E, Pittler MH, Stevinson C. Complementary/alternative medicine in dermatology: evidence-assessed efficacy of two diseases and two treatments. American Journal of Clinical Dermatology. 2002;3(5):341-348.

Farnan TB, McCallum J, Awa A, Khan AD, Hall SJ. Tea tree oil: in vitro efficacy in otitis externa. J Laryngology and Otology. 2005;119(3):198-201.

Fritz TM, Burg G, Krasovec M. Allergic contact dermatitis to cosmetics containing Melaleuca alternifolia (tea tree oil). [Article in French] Annales de Dermatologie et Venereologie. 2001;128(2):123-126.

Golab M, Skwarlo-Sonta K. Mechanisms involved in the anti-inflammatory action of inhaled tea tree oil in mice. Experimental Biology and Medicine (Maywood). 2007;232(3):420-426.

Hammer KA, Carson CF, Riley TV, Nielsen JB. A review of the toxicity of Melaleuca alternifolia (tea tree) oil. Food Chemistry and Toxicology. 2006;44(5):616-625.

Hammer KA, Carson CF, Riley TV. In-vitro activity of essential oils, in particular Melaleuca alternifolia (tea tree) oil and tea tree oil products, against Candida spp. Journal of Antimicrobial Chemotherapy. 1998;42:591-595.

Hammer KA, Carson CF, Riley TV. In vitro activity of Melaleuca alternifolia (tea tree) oil against dermatophytes and other filamentous fungi. Journal of Antimicrobial Chemotherapy. 2002;50(2):195-199.

Hammer KA, Dry L, Johnson M, Michalak EM, Carson CF, Riley TV. Susceptibility of oral bacteria to Melaleuca alternifolia (tea tree) oil in vitro. Oral Microbiology and Immunology. 2003;18(6):389-392.

Hartford O, Zug KA. Tea tree oil. Cutis. 2005;76(3):178-180.

Harkenthal M, Layh-Schmitt G, Reichling J. Effect of Australian tea tree oil on the viability of the wall-less bacterium Mycoplasma pneumoniae. Pharmazie. 2000 May;55(5):380-384.

HealthNotes, Inc. Tea Tree (Melaleuca alternifolia). 2002. Available at: http://www.mycustompak.com/healthNotes/Herb/Tea_Tree.htm Accessed March 28, 2003.

Henley DV, Lipson N, Korach KS, Bloch CA. Prepubertal gynecomastia linked to lavender and tea tree oils. New England Journal of Medicine. 2007;356(5):479-485.

Iori A, Grazioli D, Gentile E, Marano G, Salvatore G. Acaricidal properties of the essential oil of Melaleuca alternifolia Cheel (tea tree oil) against nymphs of Ixodes ricinus. Veterinary Parasitology. 2005;129(1-2):173-176.

Jacobs MR, Hornfeldt CS. Melaleuca oil poisoning. Journal of Toxicology and Clinical Toxicology. 1994;32(4):461-464.

Jandourek A, Vaishampayan JK, Vazquez JA. Efficacy of melaleuca oral solution for the treatment of fluconazole refractory oral candidiasis in AIDS patients. AIDS 1998;12(9):1033-1037.

Jellin JM, Gregory P, Batz F, Hitchens K, et al, eds. Pharmacist's Letter/Prescriber's Letter. Natural Medicines Comprehensive Database, 3rd Edition. Stockton CA: Therapeutic Research Facility, 2000.

Khanna M, Qasem K, Sasseville D. Allergic contact dermatitis to tea tree oil with erythema multiforme-like id reaction. American Journal of Contact Dermatology. 2000;11(4):238-242.

Koh KJ, Pearce AL, Marshman G, Finlay-Jones JJ, Hart PH. Tea tree oil reduces histamine-induced skin inflammation. British Journal of Dermatology. 2002;147(6):1212-1217.

Kulik E, Lenkeit K, Meyer J. Antimicrobial effects of tea tree oil (Melaleuca alternifolia) on oral microorganisms. [article in German] Schweiz Monatsschr Zahnmed. 2000;110(11):125-130.

Lis-Balchin M, Hart SL, Deans SG. Pharmacological and antimicrobial studies on different tea-tree oils (Melaleuca alternifolia, Leptospermum scoparium or Manuka and Kunzea ericoides or Kanuka), originating in Australia and New Zealand. Phytotherapy Research. 2000;14(8):623-629.

Mantle D, Gok MA, Lennard TW. Adverse and beneficial effects of plant extracts on skin and skin disorders. Adverse Drug Reactions and Toxicology Review. 2001;20(2):89-103.

May J, Chan CH, King A, Williams L, French GL. Time-kill studies of tea tree oils on clinical isolates. Journal of Antimicrobial Chemotherapy. 2000;45:639-643.

Mondello F, De Bernardis F, Girolamo A, Salvatore G, Cassone A. In vitro and in vivo activity of tea tree oil against azole-susceptible and -resistant human pathogenic yeasts. Journal of Antimicrobial Chemotherapy. 2003;51(5):1223-1229.

Morris MC, Donoghue A, Markowitz JA, Osterhoudt KC. Ingestion of tea tree oil (Melaleuca oil) by a 4-year-old boy. Pediatric Emergency Care. 2003;19(3):169-171.

Rubel DM, Freeman S, Southwell IA. Tea tree oil allergy: what is the offending agent? Report of three cases of tea tree oil allergy and review of the literature. Australasian Journal of Dermatology. 1998;39(4):244-247.

Rutherford T, Nixon R, Tam M, Tate B. Allergy to tea tree oil: retrospective review of 41 cases with positive patch tests over 4.5 years. Australasian Journal of Dermatology. 2007;48(2):83-87.

Satchell AC, Saurajen A, Bell C, Barnetson RS. Treatment of interdigital tinea pedis with 25% and 50% tea tree oil solution: a randomized, placebo-controlled, blinded study. Australasian Journal of Dermatology. 2002;43(3):175-178.

Schnitzler P, Schon K, Reichling J. Antiviral activity of Australian tea tree oil and eucalyptus oil against herpes simplex virus in cell culture. Pharmazie. 2001;56(4):343-347.

Syed TA, Qureshi ZA, Ali SM, Ahmad S, Ahmad SA. Treatment of toenail onychomycosis with 2% butenafine and 5% Melaleuca alternifolia (tea tree) oil in cream. Tropical Medicine and International Health 1999;4(4):284-287.

Takarada K, Kimizuka R, Takahashi N, Honma K, Okuda K, Kato T. A comparison of the antibacterial efficacies of essential oils against oral pathogens. Oral Microbiology and Immunology. 2004;19(1):61-64.

Terzi V, Morcia C, Faccioli P, Vale G, Tacconi G, Malnati M. In vitro antifungal activity of the tea tree (Melaleuca alternifolia) essential oil and its major components against plant pathogens. Letters in Applied Microbiology. 2007;44(6):613-618.

Tong MM, Altman PM, Barnetson RS. Tea tree oil in the treatment of tinea pedis. Australasian Journal of Dermatology. 1992;33(3):145-149.

Vazquez JA, Zawawi AA. Efficacy of alcohol-based and alcohol-free melaleuca oral solution for the treatment of fluconazole-refractory oropharyngeal candidiasis in patients with AIDS. HIV Clinical Trials. 2002;3(5):379-385.

Villar D, Knight MJ, Hansen SR, Buck WB. Toxicity of melaleuca oil and related essential oils applied topically on dogs and cats. Veterinary and Human Toxicology. 1994;36(2):139-142.

Williams JD, Nixon RL, Lee A. Recurrent allergic contact dermatitis due to allergen transfer by sunglasses. Contact Dermatitis. 2007;57(2):120-121.

Williamson EM, Priestley CM, Burgess IF. An investigation and comparison of the bioactivity of selected essential oils on human lice and house dust mites. Fitoterapia. 2007;78(7-8):521-525.

Wu J. Treatment of rosacea with herbal ingredients. Journal of Drugs in Dermatology. 2006;5(1):29-32.

Zhang SY, Robertson D. A study of tea tree oil ototoxicity. Audiology and Neurootology. 2000;5(2):64-68.

Last Revised October 19, 2007


Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.

In general, herbal products are not subject to review or approval by the U.S. Food and Drug Administration (FDA). They are not required to be standardized, meaning that the amounts of active ingredients or contaminants they contain may vary between brands or between different batches of the same brand. Not all of the risks, side effects, or interactions associated with the use of herbal products are known because few reliable studies of their use in humans have been done.

This information is provided for your education only. Please share this information with your healthcare provider and be sure that you talk to your doctor and pharmacist about all the prescription and non-prescription medicines you take before you begin to use any herbal product.

Back