Peptic Ulcer Disease
How is it treated?
Treatment recommendations of the American College of Gastroenterology are based on the understanding that PUD is usually the result of H. pylori infection, or is caused by taking aspirin and other NSAIDs. Thus, the first step is to stop taking NSAIDs or aspirin. Successful elimination of H. pylori cures most patients who are not continuing to take aspirin or an NSAID.
Patients with a prior history of PUD, active
peptic ulcer disease, or gastric lymphoma (stomach cancer),
should be tested for H. pylori infection. If they test positive, they
should be treated with antibiotic therapy. If the tests are negative for H.
pylori infection, patients are treated with traditional ulcer therapy that
blocks the production of stomach acid and protects the tissues lining the
stomach and duodenum.
For NSAID-induced ulcers, cytoprotective agents, or drugs that coat and protect the stomach mucosa, may be used.
Drug classes used to treat Peptic Ulcer Disease Antacids Cytoprotective Agents Helicobacter Pylori Treatment Regimens Histamine-2 Receptor Blockers Proton Pump Inhibitors
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