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Treatment Options

Tricyclic Antidepressants

Antidepressants increase the levels of certain chemicals, such as norepinephrine and serotonin, in the brain. Low levels of these chemicals can cause depression and are believed to be associated with the pain and tiredness experienced by FM patients. Sometimes treatment of coexistent conditions such as depression and sleep disorders improve the symptoms of fibromyalgia. Tricyclic anti-depressants (TCAs), which are used in low doses to promote sleep, are usually taken at bedtime. Some of these medicines include amitriptyline (Elavil), doxepin (Prudoxin, Sinequan), and nortriptyline (Aventyl, Pamelor).

Drugs in the class

Clomipramine Capsules (Anafranil)

Desipramine Tablets (Norpramin)

Imipramine Hydrochloride Tablets (Tofranil Tablets)

Nortriptyline (Aventyl, Pamelor)

Trimipramine Capsules (Surmontil)

Protriptyline (Vivactil)

Doxepin Capsules ()

Amitriptyline ()

Amoxapine ()

Note: The above information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist, or other healthcare professional. It is not intended to diagnose a health condition, but it can be used as a guide to help you decide if you should seek professional treatment or to help you learn more about your condition once it has been diagnosed.