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ACE-Inhibitor and Diuretic Combination
This is another class of anti-hypertensive medications that combines two different classes of blood pressure medications into a convenient single-tablet dosage form. The ACE-inhibitor and diuretic combination work together to effectively lower blood pressure.
The kidneys produce the enzyme renin, which releases the hormone angiotensin I. Angiotensin converting enzyme (ACE) converts angiotensin I to angiotensin II, which constricts blood vessels and causes the kidneys to retain more fluid. The main function of angiotensin II is to increase the blood pressure. ACE inhibitors block the conversion of angiotensin I to angiotensin II, thereby reducing constriction and helping to reduce blood pressure.
Diuretics work within the kidneys to eliminate excess fluid and sodium. The diuretic in these combination products is hydrochlorothiazide.
The combination of these two classes of blood pressure medications into a single tablet that can be taken once a day increases the likelihood that patients will be compliant (taking medications on a regular basis). Combining the ACE-inhibitor with the diuretic may also decrease the risk of hyperkalemia (increased level of potassium in the blood) that diuretics often cause.
Drugs in the class
Quinapril and Hydrochlorothiazide (Accuretic, Quinaretic)
Enalapril, Hydrochlorothiazide Tablets (Vaseretic Tablets)
Hydrochlorothiazide, Moexipril Tablets (Uniretic Tablets)
Benazepril and Hydrochlorothiazide (Lotensin HCT)
Fosinopril, Hydrochlorothiazide Tablets (Monopril HCT Tablets)
Captopril and Hydrochlorothiazide (Capozide)
Lisinopril and Hydrochlorothiazide (Prinzide, Zestoretic) | 
