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Estrogen Agonist-Antagonists

Estrogen agonist-antagonist drugs work by stimulating the pituitary gland to release the hormones that trigger sperm production or ovulation. In some body tissues, they act like estrogen to produce estrogen-like effects. However, they block (antagonize) estrogen?s effects in other tissues. While they are used occasionally for men with low testosterone or low sperm counts, estrogen agonists-antagonists are most often prescribed for women.

Commonly, an estrogen agonist-antagonist is the drug of first choice for stimulating ovulation in women who do not ovulate at all or who do not ovulate regularly, even though they have normal pituitary function. These drugs may result in ovulation rates of up to 85%. Approximately 40% of the women who ovulate after taking an estrogen agonist-antagonist eventually will become pregnant.

Drugs in the class

Clomiphene (ClomidMilopheneSerophene)


Note: The above information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist, or other healthcare professional. It is not intended to diagnose a health condition, but it can be used as a guide to help you decide if you should seek professional treatment or to help you learn more about your condition once it has been diagnosed.



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