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Treatment Options

Monoamine Oxidase Inhibitors

These drugs are used in the treatment of panic disorder, social phobia, PTSD and sometimes OCD, but they require dietary restrictions and some doctors prefer to try other treatments first. Anyone taking a MAO inhibitor must avoid other medications, wine and beer, and food such as cheeses that contain tyramine.

Of the MAOI's, Parnate (tranyclypromine, SKB) is the most commonly used. Treatment with tranyclypromine usually starts with a relatively low daily dosage that is increased gradually until panic attacks cease or the patient reaches a maximum dosage of about 60 - 80 milligrams a day:

Use of tranyclypromine or any other MAOI requires the patient to be very careful which other foods or prescription drugs they are taking. Certain foods and drugs can interact with the MAOI to cause a sudden, dangerous rise in blood pressure. All patients who are taking MAOIs should consult with their physician before using any over-the-counter or prescription medications.

As in the case of the high-potency benzodiazepines and imipramine, treatment with tranyclypromine or another MAOI generally lasts 6 months to a year. When the treatment period ends, the medication is gradually reduced over a period of weeks.

Drugs in the class

Isocarboxazid (Marplan)

Tranylcypromine (Parnate)

Phenelzine (Nardil)


Note: The above information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist, or other healthcare professional. It is not intended to diagnose a health condition, but it can be used as a guide to help you decide if you should seek professional treatment or to help you learn more about your condition once it has been diagnosed.



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