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Health Conditions

Injectable Estrogen and Progestin Combination (No longer available in the US)

Contraindications

Injectable estrogen and progestin combinations are not appropriate for women who are pregnant and for women who have or have ever had:

  • Blood clots or a clotting disorder
  • Breast cancer
  • Heart disease
  • Impaired liver function
  • Jaundice (yellowing of skin and whites of eyes) with pregnancy or with previous COC use
  • Liver cancer
  • Stroke or TIA (transient ischemic attack)
  • Unexplained abnormal vaginal bleeding

Precautions

Women with the following conditions should use injectable estrogen and progestin combinations cautiously:

  • Active gallbladder disease
  • Age over 35 years and a heavy smoker (15 or more cigarettes a day)
  • Age over 40 years with another risk factor for heart disease
  • Age over 45 years without risk factors for heart disease
  • Breast-feeding
  • Depression or a history of depression
  • High cholesterol
  • Prolonged periods of inactivity (such as bed rest after major surgery)
  • Use of some anticonvulsant, antibiotic, or antifungal drugs without other forms of contraception

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Note: The above information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist, or other healthcare professional. It is not intended to diagnose a health condition, but it can be used as a guide to help you decide if you should seek professional treatment or to help you learn more about your condition once it has been diagnosed.



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