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Herbs & Supplements

Eleutherococcus senticosus
Scientific Name: Eleuthero
Other Names: Acanthopanax senticosus, Ci Wu Jia, Devil's Bush, Russian Root, Shigoka, Siberian Ginseng, Taiga, Thorny Pepperbush, Touch-Me-Not, Wild Pepper

References

Anon. Monograph. Eleutherococcus senticosus. Alternative Medicine Review. 2006;11(2):151-155.

Asano K, Takahashi T, Miyashita M, et al. Effect of Eleutherococcus senticosus extract on human physical working capacity. Planta Medica. 1986;(3):175-177.

Awang DV. Siberian ginseng toxicity may be case of mistaken identity. Canadian Medical Association Journal. 1996;155(9):1237.

Awang DV. What in the name of Panax are those other "ginsengs"? HerbalGram. 2003;57:35-40.

Baranov AI. Medicinal uses of ginseng and related plants in the Soviet Union: recent trends in the Soviet literature. Journal of Ethnopharmacology. 1982;6(3):339-353.

Bazaz'ian GG, Liapina LA, Pastorova VE, Zvereva EG. Effect of Eleutherococcus on the functional status of the anticoagulation system in older animals. [article in Russian] Fiziol Zh SSSR Im I M Sechenova. 1987;73(10):1390-1395.

Blumenthal M. Farm bill bans use of name "ginseng" on non-Panax species: "Siberian ginseng" no longer allowed as commercial term [press release]. Austin, Texas: American Botanical Council; Fall 2002.

Chen Z, Yin CP, Liu JH, Fang JG, Wang WQ, Shi CY. Extract of acanthopanacis senticosus improves sperm motility of asthenospermia patients in vitro. [Article in Chinese] Zhonghua Nan Ke Xue. 2007;13(1):21-23.

Cicero AF, Derosa G, Brillante R, Bernardi R, Nascetti S, Gaddi A. Effects of Siberian ginseng (Eleutherococcus senticosus maxim.) on elderly quality of life: a randomized clinical trial. Archives of Gerontology and Geriatrics Supplement. 2004;(9):69-73.

Dasgupta A, Reyes MA. Effect of Brazilian, Indian, Siberian, Asian, and North American ginseng on serum digoxin measurement by immunoassays and binding of digoxin-like immunoreactive components of ginseng with Fab fragment of antidigoxin antibody (Digibind). American Journal of Clinical Pathology. 2005;124(2):229-236.

Dasgupta A, Wu S, Actor J, Olsen M, Wells A, Datta P. Effect of Asian and Siberian ginseng on serum digoxin measurement by five digoxin immunoassays. Significant variation in digoxin-like immunoreactivity among commercial ginsengs. American Journal of Clinical Pathology. 2003;119(2):298-303.

Davydov M, Krikorian AD. Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. (Araliaceae) as an adaptogen: a closer look. Journal of Ethnopharmacology. 2000;72(3):345-393.

Deyama T, Nishibe S, Nakazawa Y. Constituents and pharmacological effects of Eucommia and Siberian ginseng. Acta Pharmacol Sin. 2001;22(12):1057-1070.

Di Carlo G, Pacilio M, Capasso R, Di Carlo R. Effect on prolactin secretion of Echinacea purpurea, hypericum perforatum and Eleutherococcus senticosus. Phytomedicine. 2005;12(9):644-647.

Donovan JL, DeVane CL, Chavin KD, Taylor RM, Markowitz JS. Siberian ginseng (Eleutheroccus [sic] senticosus) effects on CYP2D6 and CYP3A4 activity in normal volunteers. Drug Metabolism and Disposition. 2003;31(5):519-522.

Dowling EA, Redondo DR, Branch JD, Jones S, McNabb G, Williams MH. Effect of Eleutherococcus senticosus on submaximal and maximal exercise performance. Medical Science in Sports and Exercise. 1996;28:482-489.

Drozd J, Sawicka T, Prosinska J. Estimation of humoral activity of Eleutherococcus senticosus. Acta Pol Pharm. 2002;59(5):395-401.

Eschbach LF, Webster MJ, Boyd JC, McArthur PD, Evetovich TK. The effect of Siberian ginseng (Eleutherococcus senticosus) on substrate utilization and performance. International Journal of Sports Nutrition and Exercise Metabolism. 2000;10(4):444-451.

Fuchikami H, Satoh H, Tsujimoto M, Ohdo S, Ohtani H, Sawada Y. Effects of herbal extracts on the function of human organic anion-transporting polypeptide OATP-B. Drug Metabolism and Disposition. 2006;34(4):577-582.

Gaffney BT, Hugel HM, Rich PA. The effects of Eleutherococcus senticosus and Panax ginseng on steroidal hormone indices of stress and lymphocyte subset numbers in endurance athletes. Life Sciences. 2001;70(4):431-442.

Gaffney BT, Hugel HM, Rich PA. Panax ginseng and Eleutherococcus senticosus may exaggerate an already existing biphasic response to stress via inhibition of enzymes which limit the binding of stress hormones to their receptors. Medical Hypotheses. 2001;56(5):567-572.

Glatthaar-Saalmuller B, Sacher F, Esperester A. Antiviral activity of an extract derived from roots of Eleutherococcus senticosus. Antiviral Research. 2001;50(3):223-228.

Gyllenhaal C, Merritt SL, Peterson SD, Block KI, Gochenour T. Efficacy and safety of herbal stimulants and sedatives in sleep disorders. Sleep Medicine Review. 2000;4(3):229-251.

Hacker B, Medon PJ. Cytotoxic effects of Eleutherococcus senticosus aqueous extracts in combination with N6-(delta 2-isopentenyl)-adenosine and 1-beta-D-arabinofuranosylcytosine against L1210 leukemia cells. Journal of Pharmaceutical Science. 1984;73(2):270-272.

Harkey MR, Henderson GL, Gershwin ME, et al. Variability in commercial ginseng products: an analysis of 25 preparations. American Journal of Clinical Nutrition. 2001;73(6):1101-1106.

Harkey MR, Henderson GL, Zhou L, et al. Effects of Siberian ginseng (Eleutherococcus senticosus) on c-DNA-expressed P450 drug metabolizing enzymes. Alternative Therapy. 2001;7:S14.

Hartz AJ, Bentler S, Noyes R, et al. Randomized controlled trial of Siberian ginseng for chronic fatigue. Psychological Medicine. 2004;34(1):51-61.

HealthNotes, Inc. Eleuthero. 2002. Available at: http://www.mycustompak.com/healthNotes/Herb/Eleuthe ro.htm Accessed March 28, 2003.

Henderson GL, Harkey MR, Gershwin ME, Hackman RM, Stern JS, Stresser DM Effects of ginseng components on c-DNA-expressed cytochrome P450 enzyme catalytic activity. Life Sciences. 1999;65(15):PL209-PL214.

Hikino H, Takahashi M, Otake K, Konno C. Isolation and hypoglycemic activity of eleutherans A, B, C, D, E, F, and G: glycans of Eleutherococcus senticosus roots. Journal of Natural Products. 1986;49(2):293-297.

Hovhannisyan AS, Abrahamyan H, Gabrielyan ES, Panossian AG. The effect of Kan Jang extract on the pharmacokinetics and pharmacodynamics of warfarin in rats. Phytomedicine. 2006;13(5):318-323.

Izzo AA, Di Carlo G, Borrelli F, Ernst E. Cardiovascular pharmacotherapy and herbal medicines: the risk of drug interaction. International Journal of Cardiology. 2005;98(1):1-14.

Jellin JM, Gregory P, Batz F, Hitchens K, et al, eds. Pharmacist's Letter/Prescriber's Letter. Natural Medicines Comprehensive Database, 3rd Edition. Stockton CA: Therapeutic Research Facility, 2000.

Jeong HJ, Koo HN, Myung NI, et al. Inhibitory effects of mast cell-mediated allergic reactions by cell cultured Siberian Ginseng. Immunopharmacology and Immunotoxicology. 2001;23(1):107-117.

Jung CH, Jung H, Shin YC, et al. Eleutherococcus senticosus extract attenuates LPS-induced iNOS expression through the inhibition of Akt and JNK pathways in murine macrophage. Journal of Ethnopharmacology. 2007;113(1):183-187.

Kwan CY, Zhang WB, Sim SM, Deyama T, Nishibe S. Vascular effects of Siberian ginseng (Eleutherococcus senticosus): endothelium-dependent NO- and EDHF-mediated relaxation depending on vessel size. Naunyn Schmiedebergs Arch Pharmacol. 2004;369(5):473-480.

Lewis WH, Zenger VE, Lynch RG. No adaptogen response of mice to ginseng and Eleutherococcus infusions. Journal of Ethnopharmacology. 1983;8(2):209-214.

McRae S. Elevated serum digoxin levels in a patient taking digoxin and Siberian ginseng. Canadian Medical Association Journal. 1996;155(3):293-295.

Medon PJ, Ferguson PW, Watson CF. Effects of Eleutherococcus senticosus extracts on hexobarbital metabolism in vivo and in vitro. Journal of Ethnopharmacology. 1984;10(2):235-241.

Narimanian M, Badalyan M, Panosyan V, et al. Randomized trial of a fixed combination (KanJang) of herbal extracts containing Adhatoda vasica, Echinacea purpurea and Eleutherococcus senticosus in patients with upper respiratory tract infections. Phytomedicine. 2005;12(8):539-547.

Palisin TE, Stacy JJ. Ginseng: is it in the root? Current Sports Medicine Report. 2006;5(4):210-214.

Panossian A, Wagner H. Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration. Phytotherapy Research. 2005;19(10):819-838.

Park EJ, Nan JX, Zhao YZ, et al. Water-soluble polysaccharide from Eleutherococcus senticosus stems attenuates fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice. Basic Clinical Pharmacology and Toxicology. 2004;94(6):298-304.

Perfect MM, Bourne N, Ebel C, Rosenthal SL. Use of complementary and alternative medicine for the treatment of genital herpes. Herpes. 2005;12(2):38-41.

Rogala E, Skopinska-Rozewska E, Sawicka T, Sommer E, Prosinska J, Drozd J. The influence of Eleuterococcus [sic] senticosus on cellular and humoral immunological response of mice. Polish Journal of Veterinary Science. 2003;6(Suppl 3):37-39.

Roxas M, Jurenka J. Colds and influenza: a review of diagnosis and conventional, botanical, and nutritional considerations. Alternative Medicine Review. 2007;12(1):25-48.

Scholz MW, Sacher F, Aicher B. The synthesis of RANTES, G-CSF, IL-4, IL-5, IL-6, IL-12, and IL-13 in human whole blood cultures is modulated by an extract from Eleutherococcus senticosus L. roots. Phytotherapy Research. 2001;15:268-270.

Shapira MY, Raphaelovich Y, Gilad L, Or R, Dumb AJ, Ingber A. Treatment of atopic dermatitis with herbal combination of Eleutherococcus, Achillea millefolium, and Lamium album has no advantage over placebo: a double blind, placebo-controlled, randomized trial. Journal of the American Academy of Dermatology. 2005;52(4):69169-3.

Sharpe PA, Granner ML, Conway JM, Ainsworth BE, Dobre M. Availability of weight-loss supplements: Results of an audit of retail outlets in a southeastern city. Journal of the American Dietetic Association. 2006;106(12):2045-2051.

Shi Z, Liu C, Li R. Effect of a mixture of Acanthopanax senticosus and Elsholtzia splendens on serum-lipids in patients with hyperlipemia. [Article in Chinese] Zhong Xi Yi Jie He Za Zhi. 1990;10(3):132 and 155-156.

Sievenpiper JL, Arnason JT, Leiter LA, Vuksan V. Decreasing, null and increasing effects of eight popular types of ginseng on acute postprandial glycemic indices in healthy humans: the role of ginsenosides. Journal of the American College of Nutrition. 2004;23(3):248-258.

Szolomicki S, Samochowiec L, Wojcicki J, Drozdzik M. The influence of active components of Eleutherococcus senticosus on cellular defense and physical fitness in man. Phytotherapy Research. 2000;14(3):30-35.

Tutel'yan AV, Klebanov GI, Il'ina SE, Lyubitskii OB. Comparative study of antioxidant properties of immunoregulatory peptides. Bulletin of Experimental Biology in Medicine. 2003;136(2):155-158.

Wang H, Actor JK, Indrigo J, Olsen M, Dasgupta A. Asian and Siberian ginseng as a potential modulator of immune function: an in vitro cytokine study using mouse macrophages. Clinica Chimica Acta. 2003;327(1-2):123-128.

Warren BS, Devine CM. Herbal Medicines and breast cancer risk. Fact Sheet #53. Cornell University Program on Breast Cancer and Environmental Risk Factors. Revised November 2004. Available at: http://envirocancer.cornell.edu/factsheet/diet/fs53 /herbal.pdf. Accessed July 14, 2005.

Webb D. Eleuthero - a detailed review of its reputed effect as an adaptogen. HerbalGram. February 6, 2001.

Yi JM, Hong SH, Kim JH, Kim HK, Song HJ, Kim HM. Effect of Acanthopanax senticosus stem on mast cell-dependent anaphylaxis. Journal of Ethnopharmacology. 2002;79(3):347-352.

Zand J. Siberian ginseng. The herb for energy and stress. Health World Online. No date given. Available at: http://healthy .net/asp/templates/article.asp?PageType=Article& ID=917. Accessed May 23, 2003.

Last Revised October 11, 2007

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Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.

In general, herbal products are not subject to review or approval by the U.S. Food and Drug Administration (FDA). They are not required to be standardized, meaning that the amounts of active ingredients or contaminants they contain may vary between brands or between different batches of the same brand. Not all of the risks, side effects, or interactions associated with the use of herbal products are known because few reliable studies of their use in humans have been done.

This information is provided for your education only. Please share this information with your healthcare provider and be sure that you talk to your doctor and pharmacist about all the prescription and non-prescription medicines you take before you begin to use any herbal product.

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