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Herbs & Supplements

Centella asiatica
Scientific Name: Gotu Kola
Other Names: Bramhi, Hydrocotyle asiatica, Indian Pennywort, Marsh Penny

References

Anon. Gotu kola. In: DerMarderosian A, Beutler JA, eds. Facts and Comparisons: The Review of Natural Products. St. Louis, MO, Facts and Comparisons. August 1996.

Babu TD, Kuttan G, Padikkala J. Cytotoxic and anti-tumour properties of certain taxa of Umbelliferae with special reference to Centella asiatica (L.) Urban. Journal of Ethnopharmacology. 1995;48(1):53-57.

Belcaro GV, Rulo A, Grimaldi R. Capillary filtration and ankle edema in patients with venous hypertension treated with TTFCA. Angiology. 1990;41(1):12-18.

Bilbao I, Aguirre A, Zabala R, Gonzalez R, Raton J, Diaz Perez JL. Allergic contact dermatitis from butoxyethyl nicotinic acid and Centella asiatica extract. Contact Dermatitis. 1995;33(6):435-436.

Brinkhaus B, Lindner M, Schuppan D, Hahn EG. Chemical, pharmacological and clinical profile of the east Asian medical plant Centella asiatica. Phytomedicine. 2000;7(5):4274-48.

Cauffield JS, Forbes HJ. Dietary supplements used in the treatment of depression, anxiety, and sleep disorders. Lippincotts Primary Care Practice. 1999;3(3):290-304.

Cheng CL, Koo MWL. Effects of Centella asiatica on ethanol induced gastric mucosal lesions in rats. Life Sciences. 2000;67(21):2647-2653.

Coldren CD, Hashim P, Ali JM, Oh SK, Sinskey AJ, Rha C. Gene expression changes in the human fibroblast induced by Centella asiatica triterpenoids. Planta Medica. 2003;69(8):725-732.

Eun HC, Lee AY. Contact dermatitis due to madecassol. Contact Dermatitis. 1985;13(5):310-313.

Flora SJ, Gupta R. Beneficial effects of Centella asiatica aqueous extract against arsenic-induced oxidative stress and essential metal status in rats. Phytotherapy Research. 2007;21(10):980-988.

Gnanapragasam A, Yogeeta S, Subhashini R, Ebenezar KK, Sathish V, Devaki T. Adriamycin induced myocardial failure in rats: protective role of Centella asiatica. Molecular and Cellular Biochemistry. 2007;294(1-2):55-63.

Gupta YK, Veerendra Kumar MH, Srivastava AK. Effect of Centella asiatica on pentylenetetrazole-induced kindling, cognition and oxidative stress in rats. Pharmacology, Biochemistry and Behavior. 2003;74(3):579-585.

Hausen BM. Centella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer. Contact Dermatitis. 1993;29(4):175-179.

Herbs2000. Gotu kola. Centella asiatica syn. Hydrocotyle asiatica. No date given. Available at: http://www.herbs2000.com/herbs/herbs_gotu_kola.htm. Accessed November 4, 2003.

Izu R, Aguirre A, Gil N, Diaz-Perez JL. Allergic contact dermatitis from a cream containing Centella asiatica extract. Contact Dermatitis. 1992;26(3):192-193.

Jayashree G, Kurup Muraleedhara G, Sudarslal S, Jacob VB. Anti-oxidant activity of Centella asiatica on lymphoma-bearing mice. Fitoterapia. 2003;74(5):431-434.

Jellin JM, Gregory P, Batz F, Hitchens K, et al, eds. Pharmacist's Letter/Prescriber's Letter. Natural Medicines Comprehensive Database, 3rd Edition. Stockton CA: Therapeutic Research Facility, 2000.

Maquart FX, Chastang F, Simeon A, Birembaut P, Gillery P, Wegrowski Y. Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds. European Journal of Dermatology. 1999;9(4):289-296.

Martinez MJ, Bonfill X, Moreno RM, Vargas E, Capella D. Phlebotonics for venous insufficiency. Cochrane Database Systematic Review. 2005;(3):CD003229.

McCaleb R, Morien K, Schlott T. Market report on herbs and spices. Herb Research Foundation. April 2000. Available at: http://www.herbs.org/africa/marketreport0400.html. Accessed November 28, 2003.

Mook-Jung I, Shin JE, Yun SH, et al. Protective effects of asiaticoside derivatives against beta-amyloid neurotoxicity. Journal of Neuroscience Research. 1999;58(3):417-425.

Mukherjee PK, Kumar V, Houghton PJ. Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity. Phytotherapy Research. 2007;21(12):1142-1145.

Plants for a Future Database. Centella asiatica. No date given. Available at: http://www.ibiblio.org/pfaf/cgi-bin/arr_html?Centella+asiatica. Accessed November 28, 2003.

Pointel JP, Boccalon H, Cloarec M, Ledevehat C, Joubert M. Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs. Angiology. 1987;38(1 Pt 1):46-50.

Ramanathan M, Sivakumar S, Anandvijayakumar PR, Saravanababu C, Pandian PR. Neuroprotective evaluation of standardized extract of Centella asciatica [sic] in monosodium glutamate treated rats. Indian Journal of Experimental Biology. 2007;45(5):425-431.

Sastravaha G, Yotnuengnit P, Booncong P, Sangtherapitikul P. Adjunctive periodontal treatment with Centella asiatica and Punica granatum extracts. A preliminary study. Journal of the International Academy of Periodontology. 2003;5(4):106-115.

Satake T, Kamiya K, An Y, Oishi Nee Taka T, Yamamoto J. The anti-thrombotic active constituents from Centella asiatica. Biology and Pharmacy Bulletin. 2007;30(5):935-940.

Shetty BS, Udupa SL, Udupa AL, Somayaji SN. Effect of Centella asiatica L (Umbelliferae) on normal and dexamethasone-suppressed wound healing in Wistar Albino rats. International Journal of Lower Extremity Wounds. 2006;5(3):1371-43.

Shukla A, Rasik AM, Jain GK, Shankar R, Kulshrestha DK, Dhawan BN. In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. Journal of Ethnopharmacology. 1999;65(1):1-11.

Siddique YH, Ara G, Beg T, Faisal M, Ahmad M, Afzal M. Antigenotoxic role of Centella asiatica L. extract against cyproterone acetate induced genotoxic damage in cultured human lymphocytes. Toxicology In Vitro. Epublished ahead of print. July 18, 2007.

Wijeweera P, Arnason JT, Koszycki D, Merali Z. Evaluation of anxiolytic properties of Gotukola--(Centella asiatica) extracts and asiaticoside in rat behavioral models. Phytomedicine. 2006;13(9-10):668-676.

Last Revised July 31, 2008

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Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.

In general, herbal products are not subject to review or approval by the U.S. Food and Drug Administration (FDA). They are not required to be standardized, meaning that the amounts of active ingredients or contaminants they contain may vary between brands or between different batches of the same brand. Not all of the risks, side effects, or interactions associated with the use of herbal products are known because few reliable studies of their use in humans have been done.

This information is provided for your education only. Please share this information with your healthcare provider and be sure that you talk to your doctor and pharmacist about all the prescription and non-prescription medicines you take before you begin to use any herbal product.

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References